The Brain in Business: The Case for Organisational Cognitive Neuroscience?

The application of cognitive neuroscientific techniques to understanding social behaviour has resulted in many discoveries. Yet advocates of the ‘social cognitive neuroscience’ approach maintain that it suffers from a number of limitations. The most notable of these is its distance from any form of real-world applicability. One solution to this limitation is ‘Organisational Cognitive Neuroscience’ – the study of the cognitive neuroscience of human behaviour in, and in response to, organizations. Given that all of us will spend most of our lives in some sort of work related organisation, organisational cognitive neuroscience allows us to examine the cognitive underpinnings of social behaviour that occurs in what may be our most natural ecology. Here we provide a brief overview of this approach, a definition and also some possible questions that the new approach would be best suited to address

Episcleral Venous Pressure and the Ocular Hypotensive Effects of Topical and Intracameral Prostaglandin Analogs.

There is a limit beyond which increasing either the concentration of a prostaglandin analog (PGA) or its dosing frequency fails to produce increases in ocular hypotensive efficacy with topical dosing. Intracameral PGA dosing with a bimatoprost implant, however, does not exhibit the same intraocular pressure (IOP)-lowering plateau at studied concentrations, and the maximum-achievable ocular hypotensive effects are not yet known. This suggests that the bimatoprost intracameral implant may activate another mechanism of action in addition to the mechanism(s) activated by topical application. Episcleral venous pressure (EVP) is a key determinant of IOP, and experimental manipulation of the episcleral vasculature can change both EVP and IOP. The recent observation that topical and intracameral PGA drug delivery routes produce different patterns of conjunctival hyperemia suggested that the differences in the IOP-lowering profiles may be caused by differing effects on the episcleral vasculature. Recent experiments in animals have shown that topical PGAs increase EVP, while the bimatoprost intracameral implant causes a smaller, transient increase in EVP, followed by a sustained decrease. The increase in EVP could be limiting the IOP-lowering efficacy of topical PGAs. In contrast, the decrease in EVP associated with the bimatoprost implant could explain its enhanced IOP-lowering effects. Further research on EVP as a target for IOP lowering is indicated to improve our understanding of this potentially important pathway for treating patients with glaucoma

k-server via multiscale entropic regularization

We present an $O((\log k)^2)$-competitive randomized algorithm for the $k$-server problem on hierarchically separated trees (HSTs). This is the first $o(k)$-competitive randomized algorithm for which the competitive ratio is independent of the size of the underlying HST. Our algorithm is designed in the framework of online mirror descent where the mirror map is a multiscale entropy. When combined with Bartal's static HST embedding reduction, this leads to an $O((\log k)^2 \log n)$-competitive algorithm on any $n$-point metric space. We give a new dynamic HST embedding that yields an $O((\log k)^3 \log \Delta)$-competitive algorithm on any metric space where the ratio of the largest to smallest non-zero distance is at most $\Delta$

Extending the baseline: Spitzer Mid-Infrared Photometry of Globular Cluster Systems in the Centaurus A and Sombrero Galaxies

Spitzer IRAC mid-infrared photometry is presented for the globular cluster (GC) systems of the NGC 5128 ("Centaurus A") and NGC 4594 ("Sombrero") galaxies. Existing optical photometric and spectroscopic are combined with this new data in a comprehensive optical to mid-IR colour catalogue of 260 GCs. Empirical colour-metallicity relationships are derived for all optical to mid-IR colour combinations. These colours prove to be very effective quantities to test the photometric predictions of simple stellar population (SSP) models. In general, four SSP models show larger discrepancies between each other and the data at bluer wavelengths, especially at high metallicities. Such differences become very important when attempting to use colour-colour model predictions to constrain the ages of stellar populations. Furthermore, the age-substructure determined from colour-colour diagrams and 91 NGC 5128 GCs with spectroscopic ages from Beasley et al. (2008) are inconsistent, suggesting any apparent GC system age-substructure implied by a colour-colour analysis must be verified independently. Unlike blue wavebands, certain optical to mid-IR colours are insensitive to the flux from hot horizontal branch stars and thus provide an excellent metallicity proxy. The NGC 5128 GC system shows strong bimodality in the optical R-band to mid-IR colour distributions, hence proving it is bimodal in metallicity. In this new colour space, a colour-magnitude trend, a "blue tilt", is found in the NGC 5128 metal-poor GC data. The NGC 5128 young GCs do not contribute to this trend. [abridged]Comment: 16 pages, 12 colour figures. To be published in MNRAS. Catalogue available from the first author. Full resolution copy available here http://lee.spitler.googlepages.com/spitzer_spitler.pd

Robust Inference for Univariate Proportional Hazards Frailty Regression Models

We consider a class of semiparametric regression models which are one-parameter extensions of the Cox [J. Roy. Statist. Soc. Ser. B 34 (1972) 187-220] model for right-censored univariate failure times. These models assume that the hazard given the covariates and a random frailty unique to each individual has the proportional hazards form multiplied by the frailty. The frailty is assumed to have mean 1 within a known one-parameter family of distributions. Inference is based on a nonparametric likelihood. The behavior of the likelihood maximizer is studied under general conditions where the fitted model may be misspecified. The joint estimator of the regression and frailty parameters as well as the baseline hazard is shown to be uniformly consistent for the pseudo-value maximizing the asymptotic limit of the likelihood. Appropriately standardized, the estimator converges weakly to a Gaussian process. When the model is correctly specified, the procedure is semiparametric efficient, achieving the semiparametric information bound for all parameter components. It is also proved that the bootstrap gives valid inferences for all parameters, even under misspecification. We demonstrate analytically the importance of the robust inference in several examples. In a randomized clinical trial, a valid test of the treatment effect is possible when other prognostic factors and the frailty distribution are both misspecified. Under certain conditions on the covariates, the ratios of the regression parameters are still identifiable. The practical utility of the procedure is illustrated on a non-Hodgkin's lymphoma dataset.Comment: Published by the Institute of Mathematical Statistics (http://www.imstat.org) in the Annals of Statistics (http://www.imstat.org/aos/) at http://dx.doi.org/10.1214/00905360400000053

A mathematical model of three-dimensional flow in a scraped-surface heat exchanger

We present a simple mathematical model of fluid flow in a Scraped-Surface Heat Exchanger (SSHE). Specifically we consider steady isothermal flow of a Newtonian fluid around a periodic array of pivoted scraper blades in a channel with one stationary and one moving wall, when there is an applied pressure gradient in a direction perpendicular to the wall motion. The flow is fully three-dimensional, but decomposes naturally into a two-dimensional transverse flow driven by the boundary motion and a longitudinal pressure-driven flow

Human Capital Spending, Inequality, and Growth in Middle-Income Asia

Asia’s rapid population aging fortifies the case for strengthening human capital investments. Further, the experience of the newly industrialized economies suggests that human capital investments will be a vital ingredient of the transition from middle income to high income. Those investments can also affect equity and public finances. In this paper, we use data from the National Transfer Accounts to empirically analyze the effect of human capital investment in Asian countries on economic growth, inequality, and fiscal balance. Our empirical evidence suggests that human capital investments have a positive effect on labor productivity and, hence, output. The positive effect is stronger for poorer households and, hence, beneficial for equity. We also find that such investments can generate sufficient tax revenues to improve the fiscal balance. Overall, our evidence points to a positive effect of human capital on growth, equity, and fiscal balance in Asia

ALTERNATIVE METHODS FOR DISTRIBUTING STATE AID TO LOCAL GOVERNMENTS IN NEW YORK

This paper simulates alternative distributions of general purpose state aid to local governments under different combinations of criteria: tax capacity, effort, and revenue needs. Revenue needs are based on Tobit estimates of the costs of providing average levels of 16 categories of services. Segmenting the sample into high and low population jurisdictions provided a more realistic set of cost estimates. Available revenues or capacity are determined by multiplying each jurisdiction's tax bases by standard tax rates. A Need-Capacity gap, the difference between needed revenues and available revenues, is used as a needs-based distribution strategy for general purpose aid. Finally an effort gap, based on above average tax efforts was added to the Need-Capacity gap to define a Need-Capacity-Effort strategy.Public Economics,